IL-17A is largely produced by activated T lymphocytes, which is a disulfide-linked homodimer and each polypeptide has 155 amino acid residues with an apparent molecular mass of 17.5 kDa. This cytokine regulates the activities of NF-kappa B and mitogen-activated protein kinases. T cell-derived IL-17A induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF. IL-17A also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) and cyclooxygenase-2 (PTGS2/COX-2) production in osteoarthritic cartilage. Recent studies have shown that IL-17A family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. Increased levels of IL-17A have been associated with airway inflammation, rheumatoid arthritis, inflammatory bowel disease, allograft rejection, psoriasis, multiple sclerosis, and cancer.

Assay Type: Solid Phase Sandwich ELISA
Format: 96-well strip plate
Assay Length: 3 hours
Sample Type & Volume Required Per Well: Cell Culture Supernates , Serum , EDTA Plasma , Heparin Plasma
Sensitivity: 7.8 pg/mL
Assay Range: 7.8-500 pg/mL (Serum, EDTA/Heparin Plasma, Cell Culture Supernates, fluid)